United States securities and exchange commission logo May 16, 2022 Jonathan W. Witter Chief Executive Officer SLM Corporation 300 Continental Drive Newark, DE 19713 Re: SLM Corporation Form 10-K for the fiscal period ending December 31, 2021 Filed February 24, 2022 File No. 001-13251 Dear Mr. Witter: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Finance